Association between Serum Heat Shock Proteins and Gamma-Delta T Cells—An Outdated Clue or a New Direction in Searching for an Anticancer Strategy? A Short Report

HSPs demonstrate a strong association with gamma-delta (γδ) T cells. Most of the studies regarding interactions between parameters were conducted in 1990s. Despite promising results, concept targeting γδ cells by seems to be forgotten direction due potent non-peptidic phosphoantigens rather than have been found essential stimulatory components for human Currently, greater knowledge lymphocyte diversity, and more accurate diagnostic methods, we decided study correlation once again neoplastic condition. Twenty-one children newly diagnosed acute lymphoblastic leukaemia (ALL) enrolled on study. Serum HSP90 concentrations evaluated an enzyme-linked immunosorbent assay (ELISA), subsets (CD3+ γδ, CD3+ HLA/DR+, CD4+ CD8+ γδ) flow cytometry. We shown statistically relevant correlations serum HLA/DR+ paediatric ALL at diagnosis (R = 0.53, p < 0.05), but not after induction chemotherapy. also demonstrated decreased levels both before treatment, which may indirectly indicate dose-dependent unknown interaction parameters. The results our good introduction research cells, could interesting development anti-cancer strategies, just childhood ALL.